The main cast of The Thundermans includes of the following:
- Kira Kosarin as Phoebe Thunderman
- Jack Griffo as Max Thunderman
- Addison Riecke as Nora Thunderman
- Diego Velazquez as Billy Thunderman
- Chris Tallman as Hank Thunderman
- Rosa Blasi as Barb Thunderman
- Maya Le Clark as Chloe Thunderman
- Dana Snyder as Dr. Colosso (voice)
- Maya Le Clark joined the cast of the Thundermans at the end of season 2 but was credited as a recurring guest star in season 3. She's officially credited as starring in season 4.
- Dana Snyder (Dr. Colosso) is not officially credited as a main character but has appeared in all episodes.