- Kira Kosarin as Phoebe Thunderman
- Jack Griffo as Max Thunderman
- Addison Riecke as Nora Thunderman
- Diego Velazquez as Billy Thunderman
- Chris Tallman as Hank Thunderman
- Rosa Blasi as Barb Thunderman
- Maya Le Clark as Chloe Thunderman
- Dana Snyder as Dr. Colosso (voice)
- The episode title is a reference to the common saying, "Come What May".
- Based on the title, there's a good chance that Dark Mayhem might return in this episode.